Inter are second in Group B, three points ahead of third-placed Spurs, who have four points.
Tottenham go into the match in good form having disposed of Chelsea in the Premier League on Saturday evening, and a similar performance to the one they produced in that clash may well be enough for Mauricio Pochettino's team to take their qualifying hopes down to the final match.
I know that Barcelona have not lost a home game for the last five years, these are the statistics I am aware of. It was starting to get tense and there was a feeling the all-important goal wasn't going to come as the clock ticked down, but we didn't panic, didn't get frustrated.
"We need fresh legs, fresh mind and no injuries".
Spurs' inability to move any of their foreign players out in turn meant they had to target homegrown talent, which saw them become the first team in Premier League history not to sign anyone during the summer transfer window.
Jan Vertonghen, who played his first match for nearly two months against Inter after recovering from a hamstring injury is looking forward to the game.
Pochettino's side will go out if they fail to beat the Italian side at Wembley.
The Barca stat that will upset Tottenham and give Inter hope
"It's a mistake we made, that at this level of football we can not repeat", Pochettino said, as reported by the BBC.
Tottenham must still beat Barcelona on December 11 at the Camp Nou to make sure of advancing to the knockout phase.
"What Barcelona is going to do is not in our hands".
"Everything is fine with Radja and there was no issue between us at the time of his substitution", said Spalletti.
"I think we can beat everyone if we're on it".
"It's going to be very competitive but of course they're qualified in first with 13 points".
"The most important is to try to avoid risk, to mix ... and rotate", Pochettino said.