While the vote was a victory for the Republican Party, politicians can vote differently on the climactic confirmation roll call, which seems likely to be on Saturday afternoon.
Judge Kavanaugh's confirmation would tilt America's highest court in favour of conservatives. Democrats hope that the roll call, exactly a month from elections in which House and Senate control are in play, will prompt infuriated women and liberals to stream to the polls to oust Republicans.
Murkowski acknowledged she agonized over her vote, telling reporters she didn't make up her mind until she walked into the Senate chamber.
Murkowski had been one of a handful of pivotal senators who remained publicly undecided on the nomination in the days leading up to Friday's vote. Every voting Republican backed the 53-year-old conservative judge.
Wisconsin Senator Ron Johnson stated: "Having spent an additional five hours reviewing the supplemental Federal Bureau of Investigation report - I will vote to confirm judge Kavanaugh to the Supreme Court".
Murkowski said based on the statements of other senators that it appeared Kavanaugh would be voted through the nomination process but that she could not support that with her vote.
Allegations against Kavanaugh arose late in the confirmation process that he sexually abused women decades ago.
Within minutes, dozens of political and advocacy groups blasted out emailed reactions.
In a statement, the court says Chief Justice John Roberts will administer the Constitutional Oath and retired Associate Justice Anthony M. Kennedy will administer the Judicial Oath in a private ceremony at the Supreme Court. "Women will not forget this".
Sen. Kirsten Gillibrand (KEER'-sten JIHL'-uh-brand) of NY says there's one fundamental question for senators when they decide Kavanaugh's fate: "Do we, as a country, value women?"
After his scheduled hearing last month, Judge Kavanaugh was embroiled in a major controversy when a professor from California, Christine Blasey Ford, alleged that she was assaulted by him when they were both teenagers in 1982.
Since then, the country watched agape as one electric moment after another gushed forth. The outcome of the investigation declared the FBI had not found any corroborating witnesses to back Ford's claim.
Both Kavanaugh and the first accuser made a dramatic testimony before the Senate Judiciary Committee which was watched live by millions of people across the world.
A total of 164 people were arrested according to U.S. Capitol Police.
A much larger crowd of protesters is watching the demonstration from behind a barricade.
The group of about 150 who somehow got around the newly-erected barricade were among about 2,000 protesters - majority women - outside the building where senators were to vote mid-afternoon.
"The more insane that comes out of the White House, the better it is for Democratic engagement across the country", Mack said. She said she respected her colleagues' support for Kavanaugh, but added: "I also that think we're at a place where we need to think about the credibility and integrity of our institutions".
"We must always remember that it is when passions are most inflamed that fairness is most in jeopardy", said Collins, perhaps the chamber's most moderate Republican.
Joe Manchin (D-WV) - two key swing votes - announced their support for Kavanaugh Friday, giving the nominee the majority he needs. It is a talking point for their continued and predictable criticism of Democrats.