It's not the first time he has been forced out of a tournament because of such an injury. But the one thing that is agreed upon unanimously is this - no one in the era of "Big Four" deserves Grand Slam glory more than Juan Martin del Potro.
'Of course, I won the Australian Open six times, never lost finals there.
Nishikori improved in the second set, coming to the net more often, but Djokovic was in imperious form. He said the discomfort surfaced in the first set, with him serving at 2-2, 15-0, and he told his coaches and supporters in his box about it.
An elbow injury in 2003 prevented his expected French Open debut that year and a stress fracture in one ankle kept him out of Roland Garros and Wimbledon in 2004.
But, yes, he's a player that went through lot of issues during his career, like me too.
But, he is now back to winning ways.
Nishikori began the third set with a confident hold of serve but the 28-year-old made four unforced errors in his next service game to set Djokovic on the road to victory. The match lasted almost five hours, did not finish until Wednesday morning, and was the longest of Nadal's US Open career.
And he will start the heavy favourite, boasting a 14-4 record over the Argentine who will be playing in just his second final at the Slams.
Bryan and Sock, seeded third, are the first team to win consecutive Grand Slam doubles titles since Mike and Bob won four in a row from 2012-13.
With Djokovic struggling, there were eight majors to be won.
While he has beaten both Nadal (2011) and Federer (2015) in finals, he lost to them both previously (Nadal - 2010, Federer 2007), while he suffered defeat to Andy Murray and Stan Wawrinka in their only clashes on that stage.
I hate to retired, but stay one more set out there playing like this will be too much for me.
Djokovic can relate to the climb back from a body breakdown.
Djokovic, who has made seven previous finals in NY but won only two, will now face Del Potro in Sunday's final. Del Potro had a 7-6 (3), 6-2 lead.
The first seed will be key.
However, no one can begrudge del Potro his second Grand Slam final. He joked that we didn't want to know about that rowdy bunch. "But the 6'6" tall Argentine also affectionately called Tower of Tandil was plagued by numerous injuries in his wrists.With so many operations and rehabs Del Potro had thoughts of calling it quits from tennis but he stuck around and with a thunderous forehand he has once again reached his peak level.
He missed around three months in 2014 and 2016 because of difficulties with wrist injuries and appendicitis.
The 31-year-old Serb, clearly enjoying the fruits of his labour, delivered a comprehensive performance against Nishikori as he served impeccably, was solid with his returns and dominated from the back of the court.