The Gaza organisers of the March of Return dubbed this weekend's demonstrations a "preparation and warning of what's to come", marking this as the last Friday before the protest peaks on Monday and Tuesday.
Numerous protesters are peaceful and Israeli officials say they only target protesters who threaten the border.
Since the protests began on March 30, at least 48 Palestinians, including five children, have been killed by Israeli snipers and almost 8,000 wounded by live fire, tear gas and "non-lethal" rubber bullets fired by Israeli soldiers.
Organizers have said the demonstrations are expected to peak on May 14th, one day before the 70th anniversary of the "Nakba" or "Catastrophe" when more than 700,000 Palestinians lost their lands to Israel in 1948.
One protestor, an 18-year-old named Mohammed, arrived at an encampment Friday in the southern Gaza Strip armed with a pair of wire cutters and a can of benzene.
On Friday, The Jerusalem Post reported that USA officials told Liberman during his visit to Washington, D.C., last week that the Trump administration plans to ask Israel to withdraw from four Arab neighborhoods in eastern Jerusalem - Jebl Mukabar, Isawiya, Shuafat and Abu Dis - and transfer control to the Palestinian Authority in order to make the area the capital of a future Palestinian state.
Thousands of Palestinians gathered at five different points along the border, AFP correspondents at the scene said.
It said seven of the 49 protesters hit by Israeli fire were in a serious condition and that dozens of others were overcome by tear gas inhalation. The analysis was based on data collected by the Palestinian Ministry of Health in Gaza. Israel says it only opens fire when necessary to stop infiltrations, damage to the fence, and attacks.
Hamas leader Yahya Sinwar declared on May 10 that he hopes that Palestinians are able to penetrate the Israel-Gaza fence during the upcoming riots, which is essentially an admission that this has been Hamas's goal all along.
"It's not right. They are living off our properties and all that we have", she said of Israelis.
She warned that the USA move will encourage Israel to accelerate its attempts to erase the Palestinian presence from occupied Jerusalem by destroying their homes and stealing their land for illegal settlements. On Friday, Palestinian protesters started fires on the Palestinian side of the crossing, damaging gas pipelines leading to the enclave, the IDF said. Israel and Egypt preserve an financial blockade of the strip, which has the best unemployment charge on the planet and has grow to be far poorer than the opposite essential Palestinian territory, the Israeli-occupied West Financial institution.
"We finally acknowledge the obvious: that Jerusalem is Israel's capital", Trump said of his decision.