According to official data, the Russian Federation has lost 13 aircraft and helicopters since that time.
Pictures have emerged on social media claiming to show the scene of the crash and smoke rising over the water.
The ministry said the plane did not come under fire and that preliminary information indicates the crash could have been caused by a bird being sucked into one of the plane's engines. Both pilots who fought until the last minute to save the plane died, said the Ministry, ruling out the possibility of an enemy attack.
Russian Federation launched the military operation in Syria on September 30, 2015.
In March, 39 people, including military personnel, were killed when a Russian transport plane crashed while trying to land at Hmeimin, Russian state media reported.