Australia's medal tally now sits at 50 gold, 38 silver and 42 bronze.
"I feel like the monkey just jumped on my back so now I must make sure I can do it again on the global scene", he said.
And the likes of Canada's Andre de Grasse had overtaken him as the possible heir to Bolt.
Instead, having been jokingly told by former training partner Bolt that there would be "problems" if he returned to Jamaica with anything less than the Commonwealth title, he was left with bronze.
Michelle-Lee Ahye held off a two-pronged Jamaican challenge to claim the women's 100m gold for Trinidad and Tobago in 11.14.
But there was delight for Andy Pozzi after the new world indoor 60m hurdles champion qualified fastest for today's 110m hurdles final.
For Simbine, however, the result was vindication.
Simbine was the talk of the athletics world after he stormed to victory out of Lane 7 in a time of 10:03. "I was just focused on myself and making sure I get to the 50 metres as quick as I can because I know if I put that together the rest of my race will come together", said the Pretoria 24-year-old.
"The 100m is an event of who's got the biggest ego and who can handle the ego the best." said Simbine, who finished fifth in the 100 at the 2016 Oylmpics.
"I wasn't focused on (Blake)". Stella Chesang fought off Kenya's Stacy Ndiwa to take the 10,000m gold for Uganda and win her maiden Commonwealth medal.
It is the first time that a South African sprinter has won the 100 metres final at the Commonwealth Games.
But, after coming up a sizeable 92cm short of that leading throw over her previous five attempts, Arnold dug out a superb 44.43m effort to complete her set of major championship medals.
Asked if he thought that at long last he had got the "monkey off his back", Bruintjies who trains at Tuks said: 'I think the "monkey" jumped right back on as I achieved something totally unexpected'.
"Holly really pushed me and the best feature is that we really push each other head to head". I was supposed to take this very easily.
Blake, who qualified fastest in 10.06s, said: "I was supposed to win easily and I suppose I was too confident and maybe I over-thought it".
The most popular win of the evening came in the T38 100m where Australian Evan O'Hanlon tore to gold in 11.09 seconds, bringing the Carrara Stadium to its feet. The path to gold was made smoother for Simbine when England runner Adam Gemili, a 4x100m relay gold medallist at the London world championships, pulled out before the final with a thigh injury.