Leicestershire Police have named four of the five victims of the Hinckley Road explosion in Leicester on Sunday (25 February).
Police said the men will remain in custody over the weekend and will appear before Leicester Magistrates on Monday.
The force of the explosion was so strong it shook nearby homes, neighbours said.
A fifth body, which is yet to be formally identified, is believed to be Shane and Sean's mum, care worker Mary Rajoobeer, 46.
One of those facing charges is from Leicester, another from nearby Coventry the third from Oldham in north-west England.
The three were remanded in custody and will appear by video link at Leicester Crown Court for their pre-trial review.
Two other arrested men have been released under investigation.
They were arrested on suspicion of conspiracy to cause an explosion and for offences under the Proceeds of Crime Act. Investigators are still trying to establish the cause of the explosion.
The explosion killed at least two members of the family that lived in the flat, brothers Shane Ragoobeer, 18, and Sean Ragoobeer, 17. Human remains were recovered from the ruins of the building after the blast, which was followed by a massive fire that injured several others on February 25.