In the opinion of USA president, Donald Trump, the nuclear agreement with Iran is bad for Washington and needs to be reviewed.
Talks are expected to focus on Iran's involvement in the Syrian Civil war and Iran's ballistic missile program, which both Le Drian and French President Emmanuel Macron have criticized Iran's missile program in recent weeks, with Le Drian stating that Iran's ballistic missile capacity anxious France "enormously".
Last week, ahead of his trip to Iran this week, French Foreign Minister Jean-Yves Le Drian's said at a news conference with Russian Foreign Minister Sergey Lavrov that Iran's ballistic missiles program "worries us enormously".
Le Drian has insisted he is not "an emissary of Trump", but he has taken a firm line on Iran's missile program and regional interventions that mirrors the rhetoric from Washington.
Zarif countered that Europe needed to "play a more constructive role to preserve" the nuclear deal, France24 TV Network said.
Trump had also vowed to stop issuing waivers on United States sanctions, while threatening to end the deal if changes are not made.
For his part, Iranian government spokesman Mohammad Baqer Nobakht said that Iran's actions in connection with defensive power is not pending on the call of the Zionist regime and the European Union and there is no topic for discussion on the table.
Still, Le Drian told The Times of Israel he is not "an emissary of Trump", and "there's still a lot of work to do on Iran's missile program".
On Tuesday, Ali Akbar Velayati, top adviser of the Supreme Leader Ayatollah Khamenei, said Iran will "never give in" to America's "bullying tactics" by trying to change the nuclear deal.
He stressed that all Iranian parties agree on the continuation of missile capabilities, noting that "some disagreements among the political groups do not prevent defending the national interests; and the defense and missile capabilities is one of them".
"Iran's defence power is not a threat to any country, and its enhancement is a function of the security needs", Shamkani was quoted by Tasnim as saying.