A bomb targeting the director of security of an Egyptian city killed one of his bodyguards and wounded four others, according to state-run Ahram news agency, citing authorities.
A device exploded beneath a parked vehicle as the convoy of the Alexandria security chief was passing in the Roman Camp street, east of the city, the ministry said in a statement.
MENA quoted Nemr as saying that two people, a policeman and a driver, were killed in the blast.
Since the ouster of Morsi and a crackdown on his Muslim Brotherhood, security forces have sought to quell attacks by extremists who have declared allegiance to the Islamic State (IS) group.
Egypt has been under a state of emergency since April a year ago, when suicide bombings struck two Coptic Christian churches on Palm Sunday in an attack claimed by the local affiliate of ISIL. While he is considered certain to win, he is seeking a large voter turnout as an endorsement of his policies.
Egypt's prosecutor-general Nabil Sadek has ordered that the High State Security and Sidi Gaber prosecution inspect the scene and take statements from the injured.
At least one policeman was killed and four others were injured in the bombing.
It has also killed scores of members of Egypt's minority Coptic Christian community in church bombings and shootings.
Sisi gave the armed forces and police a three-month deadline in November to wipe out the jihadists.